The killings follow the deadliest day in the conflict so far, after Israel killed at least 63 Palestinians and injured more than 400 on the first day of their ground invasion of the besieged coastal enclave.
Medics said that Mahmoud Zuwaid, his wife Daliah, and their children Nagham, 3, and Ruyah, 2, were killed in the attack.
Another woman who was not yet identified was also killed in the same shelling.
Palestinian medical sources said a Palestinian man was killed and several others were injured in an Israeli airstrike on a car in al-Qarara village in Khan Younis mid-day Saturday.
Earlier, Muhammad Atallah Audah Saadat, 25, was killed and seven others were injured by Israeli raids on Beit Hanoun.
Three Palestinians from the same family were also killed in an Israeli attack in Beit Hanoun.
Spokesman for the Palestinian Ministry of Health in Gaza Ashraf al-Qidra said on Saturday morning that Israeli forces had “committed a massacre against Palestinian civilians” in the Khan Younis district in the southern Gaza Strip overnight, killing eight.
He identified the victims as 20-year-old Yahya Bassam al-Serri, Muhammad Bassam al-Serri, 17, Mahmoud Ridha Salihiyya, 56, Mustafa Ridha Salihiyya, 21, Wasim Ridha Salihiyya, 15, Muhammad Mustafa Salihiyya, 22, Ibrahim Jamal Kamal Nasr, 13, and Khalid Nasr.
Twenty people were injured in the same attack including some seriously injured.
On Saturday morning, Israeli forces bombed two houses, killing a child named Muhammad Ziad al-Ruhhal and injuring dozens more.
Muhammad Abu Zaanouna, meanwhile, was killed during a strike on Abraj al-Mukhabarat in Gaza City, which also injured five others.
Al-Qidra also said that 27-year-old Raed Walid Laqan was killed in Khan Younis by an Israeli attack on a home belonging to the Tartouri family.
Shortly after that, medical sources announced the death of Khalid al-Qarra of wounds he sustained earlier on Saturday.
Israeli forces also killed 26-year-old Iyad Ismail al-Ruqab in the Bani Suheila village in the Khan Younis district.
Amjad Salim Shaath, 15 succumbed to wounds he sustained in Moraj neighborhood in Khan Younis. Two of his brothers, Ahmad and Muhammad, were killed in the same Israeli attack.
In addition, 30-year-old Said Ali Issa was killed in Juhor Addik neighborhood in the central Gaza Strip near al-Bureij refugee camp.
34-year-old Ahmad Mahmoud Hasan Aziz was killed by an Israeli missile on his home in Abraj al-Nada in the northern Gaza Strip overnight as well.
Israel launched its assault on the Gaza Strip — which it has dubbed “Operation Protective Edge” — in response to rocket fire from the area, which had increased in the weeks before the operation due to a massive Israeli military operation in the West Bank.
10 Palestinians died, more than 130 were injured, and more than 600 Hamas-affiliated individuals were arrested during that operation, which was launched following the disappearance of three Israeli youths in June.
Israel accused Hamas of being behind the disappearance, and in addition to the assault on the West Bank launched nightly airstrikes on the Ghaza Strip, which has been under a full economic blockade for the last seven years.
Hamas, however, denied the charges, and many have accused Israel of using the subsequent deaths of the three Israeli teenagers as a pretext for a widespread assault on the group.